Direct uptake and degradation of DNA by lysosomes

  title={Direct uptake and degradation of DNA by lysosomes},
  author={Yuuki Fujiwara and Hisae Kikuchi and Shu Aizawa and Akiko Furuta and Yusuke Hatanaka and Chiho Konya and Kenko Uchida and Keiji Wada and Tomohiro Kabuta},
Lysosomes contain various hydrolases that can degrade proteins, lipids, nucleic acids and carbohydrates. We recently discovered "RNautophagy," an autophagic pathway in which RNA is directly taken up by lysosomes and degraded. A lysosomal membrane protein, LAMP2C, a splice variant of LAMP2, binds to RNA and acts as a receptor for this pathway. In the present study, we show that DNA is also directly taken up by lysosomes and degraded. Like RNautophagy, this autophagic pathway, which we term… CONTINUE READING
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