Direct transmembrane clustering and cytoplasmic dimerization of focal adhesion kinase initiates its tyrosine phosphorylation.

@article{Katz2002DirectTC,
  title={Direct transmembrane clustering and cytoplasmic dimerization of focal adhesion kinase initiates its tyrosine phosphorylation.},
  author={B Z Katz and Shingo Miyamoto and Hidemi Teramoto and Muriel Zohar and Dmitry Krylov and Charles Vinson and J. Silvio Gutkind and Kenneth M Yamada},
  journal={Biochimica et biophysica acta},
  year={2002},
  volume={1592 2},
  pages={141-52}
}
We investigated mechanisms for inducing focal adhesion kinase (FAK) tyrosine phosphorylation and their ability to trigger MAP kinase signaling using transmembrane chimeras that localize FAK and its mutants to the plasma membrane. We tested whether tyrosine phosphorylation was triggered by FAK transmembrane aggregation using antibodies against the chimeric extracellular domain. Experimental clustering of chimeras containing integrin beta cytoplasmic domains or FAK induced FAK tyrosine… CONTINUE READING

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References

Publications referenced by this paper.
Showing 1-10 of 56 references

Gutkind, The small GTP-binding proteins Rac1 and Cdc42 regulate the activity of the JNK/SAPK signaling

O. A. Coso, M. Chiariello, +4 authors J.S.T. Miki
pathway, Cell • 1995
View 7 Excerpts
Highly Influenced

Shattil, Signaling networks linking integrins and rho family GTPases

S.J.M.A. Schwartz
Trends Biochem. Sci • 2000
View 1 Excerpt

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