Direct transformation from amorphous to crystalline calcium phosphate facilitated by motif-programmed artificial proteins.

@article{Tsuji2008DirectTF,
  title={Direct transformation from amorphous to crystalline calcium phosphate facilitated by motif-programmed artificial proteins.},
  author={Toru Tsuji and Kazuo Onuma and Akira Yamamoto and Mayumi Iijima and Kiyotaka Shiba},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2008},
  volume={105 44},
  pages={16866-70}
}
An animal's hard tissue is mainly composed of crystalline calcium phosphate. In vitro, small changes in the reaction conditions affect the species of calcium phosphate formed, whereas, in vivo, distinct types of crystalline calcium phosphate are formed in a well-controlled spatiotemporal-dependent manner. A variety of proteins are involved in hard-tissue formation; however, the mechanisms by which they regulate crystal growth are not yet fully understood. Clarification of these mechanisms will… CONTINUE READING