Direct transfer of extended groups from synthetic cofactors by DNA methyltransferases.

@article{Dalhoff2006DirectTO,
  title={Direct transfer of extended groups from synthetic cofactors by DNA methyltransferases.},
  author={Christian Dalhoff and Gra{\vz}vydas Lukinavi{\vc}ius and Saulius Klima{\vs}auskas and Elmar Weinhold},
  journal={Nature chemical biology},
  year={2006},
  volume={2 1},
  pages={31-2}
}
S-Adenosyl-L-methionine (AdoMet) is the major methyl donor for biological methylation reactions catalyzed by methyltransferases. We report the first chemical synthesis of AdoMet analogs with extended carbon chains replacing the methyl group and their evaluation as cofactors for all three classes of DNA methyltransferases. Extended groups containing a double or triple bond in the beta position to the sulfonium center were transferred onto DNA in a catalytic and sequence-specific manner… CONTINUE READING

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