Direct transcriptional regulation of Six6 is controlled by SoxB1 binding to a remote forebrain enhancer.

@article{Lee2012DirectTR,
  title={Direct transcriptional regulation of Six6 is controlled by SoxB1 binding to a remote forebrain enhancer.},
  author={Bumwhee Lee and Karine Rizzoti and David Soonil Kwon and Seon-Young Kim and Sangtaek Oh and Douglas J Epstein and Youngsook Son and Jaeseung Yoon and Kwanghee Baek and Yongsu Jeong},
  journal={Developmental biology},
  year={2012},
  volume={366 2},
  pages={393-403}
}
Six6, a sine oculis homeobox protein, plays a crucial and conserved role in the development of the forebrain and eye. To understand how the expression of Six6 is regulated during embryogenesis, we screened ~250 kb of genomic DNA encompassing the Six6 locus for cis-regulatory elements capable of directing reporter gene expression to sites of Six6 transcription in transgenic mouse embryos. Here, we describe two novel enhancer elements, that are highly conserved in vertebrate species and whose… CONTINUE READING

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To understand how the expression of Six6 is regulated during embryogenesis , we screened ~250 kb of genomic DNA encompassing the Six6 locus for cis - regulatory elements capable of directing reporter gene expression to sites of Six6 transcription in transgenic mouse embryos .
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