Direct tramadol application on sciatic nerve inhibits spinal somatosensory evoked potentials in rats.

@article{Tsai2001DirectTA,
  title={Direct tramadol application on sciatic nerve inhibits spinal somatosensory evoked potentials in rats.},
  author={Y. C. Tsai and Philip J Chang and I. M. Jou},
  journal={Anesthesia and analgesia},
  year={2001},
  volume={92 6},
  pages={1547-51}
}
We sought to determine the possible neural conduction blockade of tramadol and whether there is evidence of localized neural toxicity with spinal somatosensory evoked potential (SSEP) measurements. Male Wistar rats were used. SSEP, elicited by supramaximally stimulating the hind paw and recorded from the thoracolumbar and the first and second lumbar interspinous ligaments, was monitored. SSEPs were obtained before drug application as the pretreatment baseline and measured every 15 min after… CONTINUE READING