Direct thrombin inhibitors: current status and future prospects.

  • Kristi Menear
  • Published 1999 in Expert opinion on investigational drugs


Thrombin is a pivotal enzyme in the coagulation cascade and in the pathogenesis of thrombosis, which can lead to the occurrence of a number of coronary syndromes. Thrombin inhibition, by either recombinant or synthetic inhibitors, has now been recognised as a possible mechanism by which to modulate thrombosis; a cause of considerable mortality and morbidity… (More)


Figures and Tables

Sorry, we couldn't extract any figures or tables for this paper.

Slides referencing similar topics