Direct thrombin inhibitors: current status and future prospects.

  • Kristi Menear
  • Published 1999 in Expert opinion on investigational drugs

Abstract

Thrombin is a pivotal enzyme in the coagulation cascade and in the pathogenesis of thrombosis, which can lead to the occurrence of a number of coronary syndromes. Thrombin inhibition, by either recombinant or synthetic inhibitors, has now been recognised as a possible mechanism by which to modulate thrombosis; a cause of considerable mortality and morbidity… (More)

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