Direct thermodynamic and kinetic measurements of Fe²⁺ and Zn²⁺ binding to human serum transferrin.

Abstract

Human serum transferrin (hTf) is a single-chain bilobal glycoprotein that efficiently delivers iron to mammalian cells by endocytosis via the transferrin/transferrin receptor system. While extensive studies have been directed towards the study of ferric ion binding to hTf, ferrous ion interactions with the protein have never been firmly investigated owing… (More)
DOI: 10.1016/j.jinorgbio.2014.03.007

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@article{Terpstra2014DirectTA, title={Direct thermodynamic and kinetic measurements of Fe²⁺ and Zn²⁺ binding to human serum transferrin.}, author={Tyson Terpstra and Justin R McNally and T Han and Ng{\^u}yet-Thanh Ha-Duong and Jean-Michel El-Hage-Chahine and Fadi Bou-Abdallah}, journal={Journal of inorganic biochemistry}, year={2014}, volume={136}, pages={24-32} }