Direct targeting of light signals to a promoter element-bound transcription factor.

@article{MartnezGarca2000DirectTO,
  title={Direct targeting of light signals to a promoter element-bound transcription factor.},
  author={Jaime F Mart{\'i}nez-Garc{\'i}a and Enamul Huq and Peter H. Quail},
  journal={Science},
  year={2000},
  volume={288 5467},
  pages={859-63}
}
Light signals perceived by the phytochrome family of sensory photoreceptors are transduced to photoresponsive genes by an unknown mechanism. Here, we show that the basic helix-loop-helix transcription factor PIF3 binds specifically to a G-box DNA-sequence motif present in various light-regulated gene promoters, and that phytochrome B binds reversibly to G-box-bound PIF3 specifically upon light-triggered conversion of the photoreceptor to its biologically active conformer. We suggest that the… CONTINUE READING
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