Direct targeting of hippocampal neurons for apoptosis by glucocorticoids is reversible by mineralocorticoid receptor activation

@article{Crochemore2005DirectTO,
  title={Direct targeting of hippocampal neurons for apoptosis by glucocorticoids is reversible by mineralocorticoid receptor activation},
  author={Christophe Crochemore and Junfeng Lu and Yan-qiu Wu and Z Liposits and Nuno Sousa and Florian Holsboer and Osborne F X Almeida},
  journal={Molecular Psychiatry},
  year={2005},
  volume={10},
  pages={790-798}
}
An important question arising from previous observations in vivo is whether glucocorticoids can directly influence neuronal survival in the hippocampus. To this end, a primary postnatal hippocampal culture system containing mature neurons and expressing both glucocorticoid (GR) and mineralocorticoid (MR) receptors was developed. Results show that the GR agonist dexamethasone (DEX) targets neurons (microtubule-associated protein 2-positive cells) for death through apoptosis. GR-mediated cell… CONTINUE READING

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