Direct targeting of Rab-GTPase-effector interactions.

  title={Direct targeting of Rab-GTPase-effector interactions.},
  author={Jochen Spiegel and Philipp M Cromm and Aymelt Itzen and Roger S. Goody and Tom N Grossmann and Herbert Waldmann},
  journal={Angewandte Chemie},
  volume={53 9},
Small GTPases are molecular switches using GDP/GTP alternation to control numerous vital cellular processes. Although aberrant function and regulation of GTPases are implicated in various human diseases, direct targeting of this class of proteins has proven difficult, as GTPase signaling and regulation is mediated by extensive and shallow protein interfaces. Here we report the development of inhibitors of protein-protein interactions involving Rab proteins, a subfamily of GTPases, which are key… CONTINUE READING
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