Direct tandem mass spectrometry for the simultaneous assay of opioids, cocaine and metabolites in dried urine spots.

@article{OteroFernndez2013DirectTM,
  title={Direct tandem mass spectrometry for the simultaneous assay of opioids, cocaine and metabolites in dried urine spots.},
  author={Mara Otero-Fern{\'a}ndez and Jos{\'e} {\'A}ngel Cocho and Mar{\'i}a Jes{\'u}s Tabernero and Ana Mar{\'i}a Bermejo and Pilar Bermejo-Barrera and Antonio Moreda-Pi{\~n}eiro},
  journal={Analytica chimica acta},
  year={2013},
  volume={784},
  pages={25-32}
}
A micro-analytical method based on spotting urine samples (20μL) onto blood/urine spot collection cards followed by air-drying and extraction (dried urine spot, DUS) was developed and validated for the screening/confirmation assay of morphine, 6-methylacetylmorphine (6-MAM), codeine, cocaine and benzoylecgonine (BZE). Acetonitrile (3 mL) was found to be a useful solvent for target extraction from DUSs under an orbital-horizontal stirring at 180 rpm for 10 min. Determinations were performed by… CONTINUE READING