Direct synthesis of highly substituted thiophenes through copper(i)-catalyzed tandem reactions of alkylidenethiiranes with terminal alkynes.

Abstract

A novel copper(i)-catalyzed tandem addition/cycloisomerization reaction of 1-phenylsulfonylalkylidenethiiranes with terminal alkynes for the convergent assembly of 2-(alpha-phenylsulfonylalkyl)-thiophenes is reported, which could directly assemble various functional groups incorporated into the thiophene ring. 
DOI: 10.1039/b909284f

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Cite this paper

@article{Zhang2009DirectSO, title={Direct synthesis of highly substituted thiophenes through copper(i)-catalyzed tandem reactions of alkylidenethiiranes with terminal alkynes.}, author={Yiping Zhang and Ming Di Bian and Weijun Yao and Jianming Gu and Cheng Ma}, journal={Chemical communications}, year={2009}, volume={31}, pages={4729-31} }