Direct subcutaneous injection of polyethylene particles over the murine calvaria results in dramatic osteolysis

Abstract

The murine calvarial model has been widely employed for the in vivo study of particle-induced osteolysis, the most frequent cause of aseptic loosening of total joint replacements. Classically, this model uses an open surgical technique in which polyethylene (PE) particles are directly spread over the calvarium for the induction of osteolysis. We evaluated a… (More)
DOI: 10.1007/s00264-013-1887-4

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