Direct stimulation of tlr5+/+ CD11c+ cells is necessary for the adjuvant activity of flagellin.

@article{Bates2009DirectSO,
  title={Direct stimulation of tlr5+/+ CD11c+ cells is necessary for the adjuvant activity of flagellin.},
  author={John T. Bates and Satoshi Uematsu and Shizuo Akira and Steven B. Mizel},
  journal={Journal of immunology},
  year={2009},
  volume={182 12},
  pages={7539-47}
}
Flagellin is a highly effective adjuvant, but the cellular mechanism underlying this activity remains uncertain. More specifically, no consensus exists as to whether flagellin activates dendritic cells (DC) directly or indirectly. Intramuscular immunization with flagellin-OVA fusion protein resulted in enhanced in vivo T cell clustering in draining lymph nodes and IL-2 production by OVA-specific CD4(+) T cells. Immunization with flagellin-OVA also triggered greater levels of Ag-specific CD4… CONTINUE READING
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