Direct stimulation of monocyte release of interleukin 1 by mycobacterial protein antigens.

@article{Wallis1986DirectSO,
  title={Direct stimulation of monocyte release of interleukin 1 by mycobacterial protein antigens.},
  author={Robert S Wallis and Hiromi Fujiwara and Jerrold J. Ellner},
  journal={Journal of immunology},
  year={1986},
  volume={136 1},
  pages={193-6}
}
We examined stimulation of monocyte (MN) release of interleukin 1 (IL 1) by soluble microbial products. MN from tuberculin skin test nonreactive donors incubated with PPD (100 micrograms/ml) released IL 1 activity of 80.5 +/- 33.9 U/ml (mean +/- SD, n = 6), similar to that induced by optimal concentrations of LPS (76.4 U/ml). OKT3-reactive cells were not required for this process. PPD-stimulated IL 1 release by MN did not appear to be due to endotoxin contamination, as 1) PPD contained 0.01… CONTINUE READING

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