Direct stimulation of angiotensin II type 2 receptor enhances spatial memory.

@article{Jing2012DirectSO,
  title={Direct stimulation of angiotensin II type 2 receptor enhances spatial memory.},
  author={Fei Jing and Masaki Mogi and Akiko Sakata and Jun Iwanami and Kana Tsukuda and Kousei Ohshima and Li-juan Min and Ulrike Muscha Steckelings and Thomas Unger and Bj{\"o}rn Dahl{\"o}f and Masatsugu Horiuchi},
  journal={Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism},
  year={2012},
  volume={32 2},
  pages={248-55}
}
We examined the possibility that direct stimulation of the angiotensin II type 2 (AT(2)) receptor by a newly generated direct AT(2) receptor agonist, Compound 21 (C21), enhances cognitive function. Treatment with C21 intraperitoneal injection for 2 weeks significantly enhanced cognitive function evaluated by the Morris water maze test in C57BL6 mice, but this effect was not observed in AT(2) receptor-deficient mice. However, C21-induced cognitive enhancement in C57BL6 mice was attenuated by… CONTINUE READING