Direct stability-indicating method development and validation for analysis of etidronate disodium using a mixed-mode column and charged aerosol detector.

@article{Liu2008DirectSM,
  title={Direct stability-indicating method development and validation for analysis of etidronate disodium using a mixed-mode column and charged aerosol detector.},
  author={Xiao-Keng Liu and Jiang B Fang and Nina S Cauchon and Pengzu Zhou},
  journal={Journal of pharmaceutical and biomedical analysis},
  year={2008},
  volume={46 4},
  pages={639-44}
}
This paper describes the development and validation of a rapid, direct, and stability-indicating method for analysis of etidronate, a bisphosphonate compound without a UV chromophore. A mixed-mode column was used to separate etidronate from its impurities in an 8-min gradient method and a charged aerosol detector (CAD) was used for detection. The developed… CONTINUE READING