Direct single gene mutational events account for radiation-induced intestinal adenoma yields in Apc(Min/+) mice.

Abstract

Data on the induction of small intestinal tumors, predominantly adenomas, by X radiation in Apc(Min/+) mice are reported. Comparison of these incidences with estimates of radiation-induced direct single gene mutation frequencies taken from the literature support the hypothesis that direct mutational loss of Apc+ is the sole requirement for initiation of… (More)

Topics

Cite this paper

@article{Ellender2005DirectSG, title={Direct single gene mutational events account for radiation-induced intestinal adenoma yields in Apc(Min/+) mice.}, author={Michele Ellender and John D Harrison and Alan Edwards and Simon Bouffler and Roger D. Cox}, journal={Radiation research}, year={2005}, volume={163 5}, pages={552-6} }