Direct serum assay for microRNA-21 concentrations in early and advanced breast cancer.

@article{Asaga2011DirectSA,
  title={Direct serum assay for microRNA-21 concentrations in early and advanced breast cancer.},
  author={Sota Asaga and Christine Kuo and Tung Thanh Nguyen and Marilou Terpenning and Armando E. Giuliano and Dave S. B. Hoon},
  journal={Clinical chemistry},
  year={2011},
  volume={57 1},
  pages={84-91}
}
BACKGROUND MicroRNAs (miRs) are a class of small noncoding RNAs whose expression changes have been associated with cancer development and progression. Current techniques to isolate miRs for expression analysis from blood are inefficient. We developed a reverse-transcription quantitative real-time PCR (RT-qPCR) assay for direct detection of circulating miRs in serum. We hypothesized that serum concentrations of miR-21, a biomarker increased in breast tumors, would correlate with the presence and… CONTINUE READING

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