Direct role for potassium channel inhibition in hypoxic pulmonary vasoconstriction.

@article{Post1992DirectRF,
  title={Direct role for potassium channel inhibition in hypoxic pulmonary vasoconstriction.},
  author={Joe M. Post and Joseph R. Hume and Stephen L Archer and Edward Kenneth Weir},
  journal={The American journal of physiology},
  year={1992},
  volume={262 4 Pt 1},
  pages={C882-90}
}
Cellular mechanisms responsible for hypoxic pulmonary vasoconstriction were investigated in pulmonary arterial cells, isolated perfused lung, and pulmonary artery rings. Three K+ channel antagonists, Leiurus quinquestriatus venom, tetraethylammonium, and 4-aminopyridine, mimicked the effects of hypoxia in isolated lung and arterial rings by increasing pulmonary artery pressure and tension and also inhibited whole cell K+ currents in isolated pulmonary arterial cells. Reduction of oxygen tension… CONTINUE READING

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