Direct role for Myc in transcription initiation mediated by interactions with TFII-I

@article{Roy1993DirectRF,
  title={Direct role for Myc in transcription initiation mediated by interactions with TFII-I},
  author={A. Roy and C. Carruthers and T. Gutjahr and R. Roeder},
  journal={Nature},
  year={1993},
  volume={365},
  pages={359-361}
}
THE nuclear proto-oncoprotein Myc has been implicated in the control of cell proliferation and differentiation1–3. Myc participates in transcription4,5 and belongs to the basic–helix–loop–helix (bHLH) family of regulatory proteins2,3. Here we show that Myc interacts with TFII-I, a transcription initiation factor that activates core promoters through an initiator element (Inr)6. As previously observed for the bHLH activator USF6, Myc was found to interact cooperatively with TFII-I at both Inr… Expand
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