Direct reprogramming of somatic cells is promoted by maternal transcription factor Glis1

@article{Maekawa2011DirectRO,
  title={Direct reprogramming of somatic cells is promoted by maternal transcription factor Glis1},
  author={M. Maekawa and K. Yamaguchi and Tomonori Nakamura and R. Shibukawa and Ikumi Kodanaka and T. Ichisaka and Y. Kawamura and Hiromi Mochizuki and N. Goshima and S. Yamanaka},
  journal={Nature},
  year={2011},
  volume={474},
  pages={225-229}
}
Induced pluripotent stem cells (iPSCs) are generated from somatic cells by the transgenic expression of three transcription factors collectively called OSK: Oct3/4 (also called Pou5f1), Sox2 and Klf4. However, the conversion to iPSCs is inefficient. The proto-oncogene Myc enhances the efficiency of iPSC generation by OSK but it also increases the tumorigenicity of the resulting iPSCs. Here we show that the Gli-like transcription factor Glis1 (Glis family zinc finger 1) markedly enhances the… Expand
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