Direct reprogramming of human fibroblasts to functional and expandable hepatocytes.


The generation of large numbers of functional human hepatocytes for cell-based approaches to liver disease is an important and unmet goal. Direct reprogramming of fibroblasts to hepatic lineages could offer a solution to this problem but so far has only been achieved with mouse cells. Here, we generated human induced hepatocytes (hiHeps) from fibroblasts by… (More)
DOI: 10.1016/j.stem.2014.01.003


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