Direct reprogramming of fibroblasts into endothelial cells capable of angiogenesis and reendothelialization in tissue-engineered vessels.

@article{Margariti2012DirectRO,
  title={Direct reprogramming of fibroblasts into endothelial cells capable of angiogenesis and reendothelialization in tissue-engineered vessels.},
  author={Andriana Margariti and Bernhard Winkler and Eirini Karamariti and Anna Zampetaki and Tsung-neng Tsai and Dilair F. Baban and Jiannis Ragoussis and Yi Huang and Jing-Dong Jackie Han and Lingfang Zeng and Yanhua Hu and Qingbo Xu},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2012},
  volume={109 34},
  pages={
          13793-8
        }
}
The generation of induced pluripotent stem (iPS) cells is an important tool for regenerative medicine. However, the main restriction is the risk of tumor development. In this study we found that during the early stages of somatic cell reprogramming toward a pluripotent state, specific gene expression patterns are altered. Therefore, we developed a method to generate partial-iPS (PiPS) cells by transferring four reprogramming factors (OCT4, SOX2, KLF4, and c-MYC) to human fibroblasts for 4 d… CONTINUE READING
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