Direct reprogramming of adult human fibroblasts to functional neurons under defined conditions.

@article{Ambasudhan2011DirectRO,
  title={Direct reprogramming of adult human fibroblasts to functional neurons under defined conditions.},
  author={Rajesh Ambasudhan and Maria Talantova and Ronald Coleman and Xu Wang Yuan and Saiyong Zhu and Stuart A Lipton and Sheng Ding},
  journal={Cell stem cell},
  year={2011},
  volume={9 2},
  pages={
          113-8
        }
}
Human induced pluripotent stem cells (hiPSCs) have been generated by reprogramming a number of different somatic cell types using a variety of approaches. In addition, direct reprogramming of mature cells from one lineage to another has emerged recently as an alternative strategy for generating cell types of interest. Here we show that a combination of a microRNA (miR-124) and two transcription factors (MYT1L and BRN2) is sufficient to directly reprogram postnatal and adult human primary dermal… CONTINUE READING

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