Direct repression of Sonic Hedgehog expression in the stomach by Cdx2 leads to intestinal transformation.

@article{Mutoh2010DirectRO,
  title={Direct repression of Sonic Hedgehog expression in the stomach by Cdx2 leads to intestinal transformation.},
  author={Hiroyuki Mutoh and Hiroko Hayakawa and Miho Sashikawa and Hirotsugu Sakamoto and Kentaro Sugano},
  journal={The Biochemical journal},
  year={2010},
  volume={427 3},
  pages={
          423-34
        }
}
Shh (Sonic Hedgehog) is a morphogen involved in gastric fundic gland differentiation in the adult. Shh expression is reduced in Helicobacter pylori-associated intestinal metaplastic change of the gastric epithelium and mice that lack Shh show intestinal transformation of the gastric mucosa. Similarly, in the stomach of Cdx2 (caudal-type homeobox 2)-transgenic mice, the gastric mucosa is replaced by intestinal metaplastic mucosa. The aim of the present study was to use Cdx2-transgenic mice to… CONTINUE READING

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CDX2 precedes that of CDX1 during the progression of intestinal metaplasia

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