Direct renin inhibition — a new way of targeting the renin system

@article{Brown2006DirectRI,
  title={Direct renin inhibition — a new way of targeting the renin system},
  author={Morris J. Brown},
  journal={Journal of the Renin-Angiotensin-Aldosterone System},
  year={2006},
  volume={7},
  pages={S11 - S7}
}
  • Morris J. Brown
  • Published 1 June 2006
  • Medicine
  • Journal of the Renin-Angiotensin-Aldosterone System
The renin system plays a key role in the pathology of hypertension and is influenced, both directly and indirectly, by most antihypertensive agents. The system is the target of several established classes of antihypertensive agents including angiotensin-converting enzyme inhibitors, angiotensin receptor blockers, and beta-blockers. Of currently available drugs, only the beta-blockers suppress renin secretion, but these also reduce heart rate and cardiac output. Calcium channel blockers and… Expand
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