Direct release of parathyroid hormone fragments from functioning bovine parathyroid glands in vitro.

@article{Hanley1978DirectRO,
  title={Direct release of parathyroid hormone fragments from functioning bovine parathyroid glands in vitro.},
  author={David Arthur Hanley and Kiyoshi Takatsuki and J M Sultan and Arthur B. Schneider and Louis M. Sherwood},
  journal={The Journal of clinical investigation},
  year={1978},
  volume={62 6},
  pages={1247-54}
}
To determine the origin of circulating parathyroid hormone fragments, hormonal peptides released from bovine parathyroid tissue in a physiologically responsive in vitro "perifusion" system were analyzed by gel exclusion chromatography and region-specific radioimmunoassays. When exposed to low Ca++, the tissue released large quantities of intact hormone (parathyroid hormone 1--84) as well as amino- and carboxyl-terminal fragments. Fragments of the hormone were also released when the tissue was… CONTINUE READING

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