Direct regulatory effect of fatty acids on macrophage lipoprotein lipase: potential role of PPARs.

@article{Michaud2001DirectRE,
  title={Direct regulatory effect of fatty acids on macrophage lipoprotein lipase: potential role of PPARs.},
  author={Sherri E Michaud and Genevi{\`e}ve Renier},
  journal={Diabetes},
  year={2001},
  volume={50 3},
  pages={660-6}
}
Atherosclerosis is a major complication of type 2 diabetes. The pathogenesis of this complication is poorly understood, but it clearly involves production in the vascular wall of macrophage (Mo) lipoprotein lipase (LPL). Mo LPL is increased in human diabetes. Peripheral factors dysregulated in diabetes, including glucose and free fatty acids (FAs), may contribute to this alteration. We previously reported that high glucose stimulates LPL production in both J774 murine and human Mo. In the… CONTINUE READING
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