Direct regulation of smooth muscle contractile elements by second messengers.

@article{Nishimura1989DirectRO,
  title={Direct regulation of smooth muscle contractile elements by second messengers.},
  author={Junji Nishimura and Casey van Breemen},
  journal={Biochemical and biophysical research communications},
  year={1989},
  volume={163 2},
  pages={929-35}
}
The effects of adenosine 3',5'-cyclic monophosphate (cAMP), guanosine 3',5'-cyclic monophosphate (cGMP) and phorbol 12,13 dibutyrate (PDBu) on the Ca2+ sensitivity of the contractile elements in the rat mesenteric artery were investigated, using a method of permeabilizing smooth muscle with Staphylococcal alpha-toxin. Both cAMP and cGMP relaxed the… CONTINUE READING