Direct regulation of rhodopsin 1 by Pax-6/eyeless in Drosophila: evidence for a conserved function in photoreceptors.

@article{Sheng1997DirectRO,
  title={Direct regulation of rhodopsin 1 by Pax-6/eyeless in Drosophila: evidence for a conserved function in photoreceptors.},
  author={Guojun Sheng and Eric Thouvenot and Dietmar Schmucker and David Sloane Wilson and Claude Desplan},
  journal={Genes & development},
  year={1997},
  volume={11 9},
  pages={
          1122-31
        }
}
Pax-6 is a transcription factor containing both a homeodomain (HD) and a Paired domain (PD). It functions as an essential regulator of eye development in both Drosophila and vertebrates, suggesting an evolutionarily conserved origin for different types of metazoan eyes. Classical morphological and phylogenetic studies, however, have concluded that metazoan eyes have evolved many times independently. These apparently contradictory findings may be reconciled if the evolutionarily ancient role of… CONTINUE READING

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