Direct regulation of prokaryotic Kir channel by cholesterol.


Our earlier studies have shown that channel activity of Kir2 subfamily of inward rectifiers is strongly suppressed by the elevation of cellular cholesterol. The goal of this study is to determine whether cholesterol suppresses Kir channels directly. To achieve this goal, purified prokaryotic Kir (KirBac1.1) channels were incorporated into liposomes of… (More)
DOI: 10.1074/jbc.M109.011221

Cite this paper

@article{Singh2009DirectRO, title={Direct regulation of prokaryotic Kir channel by cholesterol.}, author={Dev K. Singh and Avia Rosenhouse-Dantsker and Colin G Nichols and Decha Enkvetchakul and Irena Levitan}, journal={The Journal of biological chemistry}, year={2009}, volume={284 44}, pages={30727-36} }