Direct regulation of membrane type 1 matrix metalloproteinase following myocardial infarction causes changes in survival, cardiac function, and remodeling.

@article{Zavadzkas2011DirectRO,
  title={Direct regulation of membrane type 1 matrix metalloproteinase following myocardial infarction causes changes in survival, cardiac function, and remodeling.},
  author={Juozas A Zavadzkas and Rupak Mukherjee and William T Rivers and Risha K. Patel and Evan Meyer and Laurel E Black and Richard A. McKinney and J Marshall Oelsen and Robert E. Stroud and Francis G. Spinale},
  journal={American journal of physiology. Heart and circulatory physiology},
  year={2011},
  volume={301 4},
  pages={H1656-66}
}
The membrane type 1 matrix metalloproteinase (MT1-MMP) is increased in left ventricular (LV) failure. However, the direct effects of altered MT1-MMP levels on survival, LV function, and geometry following myocardial infarction (MI) and the proteolytic substrates involved in this process remain unclear. MI was induced in mice with cardiac-restricted overexpression of MT1-MMP (MT1-MMPexp; full length human), reduced MT1-MMP expression (heterozygous; MT1-MMP(+/-)), and wild type. Post-MI survival… CONTINUE READING

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Cardiac restricted over-expression of membrane type-1 matrix metalloproteinase in mice: effects on myocardial remodeling following myocardial infarction

  • FG Spinale, GP Escobar, +8 authors AJ. Sinusas
  • J Biol Chem
  • 2010
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