Direct regulation of lipolysis by interleukin-15 in primary pig adipocytes.

@article{Ajuwon2004DirectRO,
  title={Direct regulation of lipolysis by interleukin-15 in primary pig adipocytes.},
  author={Kolapo M Ajuwon and Michael E. Spurlock},
  journal={American journal of physiology. Regulatory, integrative and comparative physiology},
  year={2004},
  volume={287 3},
  pages={R608-11}
}
We recently provided evidence that interleukin-15 (IL-15) is expressed lowly in the pig adipocyte and that interferon-gamma (IFN-gamma) markedly increases this expression through a pathway regulated in part by protein kinase C. In the present study, we tested the hypothesis that IL-15 acts directly on the adipocyte to regulate lipid accretion by enhancing lipolysis or suppressing lipogenesis. Using recombinant porcine IL-15, we determined that this cytokine stimulates lipolysis in a dose… CONTINUE READING