Direct regulation of gonadotropin release by neurokinin B in tilapia (Oreochromis niloticus).

@article{Biran2014DirectRO,
  title={Direct regulation of gonadotropin release by neurokinin B in tilapia (Oreochromis niloticus).},
  author={Jakob Biran and Matan Golan and Naama Mizrahi and Satoshi Ogawa and Ishwar S Parhar and Berta Levavi-Sivan},
  journal={Endocrinology},
  year={2014},
  volume={155 12},
  pages={
          4831-42
        }
}
Neurokinin B (NKB) was recently identified as a key regulator of reproduction in mammals and fish. Fish were found to possess a specific novel neurokinin termed NKF. To study the role of NKB/NKF in the regulation of fish reproduction and to investigate the role of NKB/NKF and their receptors in the piscine pituitary, we have identified the NKB/tachikinin 3 receptor (tac3r) system in tilapia. Bioinformatics and phylogenetic analyses have demonstrated that the tilapia holds 1 putative tac3 gene… 
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Some inhibitory roles of NKBRP in reproduction of mature female Nile tilapia are indicated, although their exact functions are not clear at the moment.
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TLDR
A potential dual inhibitory role of the four peptides encoded by the two tac3 genes in eel reproduction, exerted at the pituitary level on both luteinizing hormone and GnRH receptor is revealed.
Neurokinin B in a flatfish species, the half-smooth tongue sole (Cynoglossus semilaevis), and its potential role in reproductive functions
  • Bin Wang, Aijun Cui, +4 authors Xuezhou Liu
  • Biology
    Aquaculture Reports
  • 2021
TLDR
The results encompass the first study reporting the existence of tac3 gene in a flatfish species and suggest its possible involvement in the control of reproduction in the half-smooth tongue sole.
Novel Functional Role of NK3R Expression in the Potentiating Effects on Somatolactin α Autoregulation in grass carp pituitary cells
TLDR
It is suggested that local release of SLα via functional interactions with IGF-I/-II and TAC3/NK3R system may constitute a potent stimulatory signal for SLα gene expression in the carp pituitary via up-regulation of NK3R expression.
Irisin stimulates gonadotropins gene expression in tilapia (Oreochromis niloticus) pituitary cells.
TLDR
Evidence is provided that irisin may serve as a novel intrapituitary factor maintaining gonadotropins gene expression in tilapia pituitary and stimulated both LHβ and FSHβ mRNA levels in vivo and in vitro.
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