Direct regulation of ZAP-70 by SHP-1 in T cell antigen receptor signaling.

  title={Direct regulation of ZAP-70 by SHP-1 in T cell antigen receptor signaling.},
  author={David R. Plas and Randall L. Johnson and Jeanette T. Pingel and Robt. Matthews and M. C. Dalton and Garbi{\~n}e Roy and Andrew Che-On Chan and Matthew L. Thomas},
  volume={272 5265},
The threshold at which antigen triggers lymphocyte activation is set by the enzymes that regulate tyrosine phosphorylation. Upon T cell activation, the protein tyrosine phosphatase SHP-1 was found to bind to the protein tyrosine kinase ZAP-70. This interaction resulted in an increase in SHP-1 phosphatase activity and a decrease in ZAP-70 kinase activity. Expression of a dominant negative mutant of SHP-1 in T cells increased the sensitivity of the antigen receptor. Thus, SHP-1 functions as a… CONTINUE READING
Highly Influential
This paper has highly influenced 10 other papers. REVIEW HIGHLY INFLUENTIAL CITATIONS


Publications citing this paper.
Showing 1-10 of 130 extracted citations

Identification of p 130 Cas as a substrate of Yersinia

James B.Bliska
View 10 Excerpts
Highly Influenced

Perspectives for computer modeling in the study of T cell activation.

Cold Spring Harbor perspectives in biology • 2010
View 14 Excerpts
Highly Influenced

Protein tyrosine phosphorylation in T cell signaling.

Frontiers in bioscience : a journal and virtual library • 2002
View 20 Excerpts
Highly Influenced

Modelling T Cell Activation

View 7 Excerpts
Highly Influenced

Similar Papers

Loading similar papers…