Direct regulation of ZAP-70 by SHP-1 in T cell antigen receptor signaling.

@article{Plas1996DirectRO,
  title={Direct regulation of ZAP-70 by SHP-1 in T cell antigen receptor signaling.},
  author={David R. Plas and Randall L. Johnson and Jeanette T. Pingel and Robt. Matthews and M. C. Dalton and Garbi{\~n}e Roy and Andrew Che-On Chan and Matthew L. Thomas},
  journal={Science},
  year={1996},
  volume={272 5265},
  pages={1173-6}
}
The threshold at which antigen triggers lymphocyte activation is set by the enzymes that regulate tyrosine phosphorylation. Upon T cell activation, the protein tyrosine phosphatase SHP-1 was found to bind to the protein tyrosine kinase ZAP-70. This interaction resulted in an increase in SHP-1 phosphatase activity and a decrease in ZAP-70 kinase activity. Expression of a dominant negative mutant of SHP-1 in T cells increased the sensitivity of the antigen receptor. Thus, SHP-1 functions as a… CONTINUE READING
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