Direct regulating effects of transforming growth factor-beta 1 on lactate production in cultured porcine Sertoli cells.

@article{Esposito1991DirectRE,
  title={Direct regulating effects of transforming growth factor-beta 1 on lactate production in cultured porcine Sertoli cells.},
  author={Giovanni Esposito and Michele Keramidas and Claire Mauduit and Jean Jacques Feige and Aram Morera and Mohamed Benahmed},
  journal={Endocrinology},
  year={1991},
  volume={128 3},
  pages={1441-9}
}
In the present study we have tested the direct effects of transforming growth factor-beta 1 (TGF beta 1) on lactate production by Sertoli cells isolated from immature porcine testes. In Sertoli cells cultured in a defined medium, TGF beta 1 was shown to stimulate lactate production in a time- and dose-dependent manner. The maximal and half-maximal effects of TGF beta 1 on lactate production were obtained in the picomolar concentration range, respectively 24 and 8 pM TGF beta 1. TGF beta 1… CONTINUE READING