Direct reaction of oximes with crotylsarin, cyclosarin, or VX in vitro

@article{Becker2006DirectRO,
  title={Direct reaction of oximes with crotylsarin, cyclosarin, or VX in vitro},
  author={G. Becker and A. Kawan and D. Gutzeit and F. Worek and L. Szinicz},
  journal={Archives of Toxicology},
  year={2006},
  volume={81},
  pages={415-420}
}
The direct reaction of seven pyridinium oximes with the organophosphorus compounds (OPCs) crotylsarin, cyclosarin, and VX was studied by spectrophotometry. This method allows to quantify different parameters: (a) the half-life times (t1/2) of the oxime-OPC reactions on the basis of the changes in the absorption at the zwitterion (betaine) peak maximum, (b) the first- and second-order rate constants (k1, k2), and (c) the maximum reaction velocities (vmax). The results of the study show that the… Expand
Chromatographic analysis of toxic phosphylated oximes (POX): a brief overview.
Functionalized cyclodextrins bearing an alpha nucleophile--a promising way to degrade nerve agents.
Combined Pre- and Posttreatment of Paraoxon Exposure
...
1
2
...

References

SHOWING 1-10 OF 23 REFERENCES
Direct reaction of oximes with sarin, soman, or tabun in vitro
The reactivation by oximes of phosphonylated acetylcholinesterase: the possible erroneous interpretation of reactivating potency.
The phosphoryl oxime-destroying activity of human plasma
Characterization of O,O-diethylphosphoryl oximes as inhibitors of cholinesterases and substrates of phosphotriesterases.
Anticholinesterase activity and rate of decomposition of some phosphylated oximes.
Combined effect of organophosphorus hydrolase and oxime on the reactivation rate of diethylphosphoryl-acetylcholinesterase conjugates.
Effect of human plasma on the reactivation of sarin-inhibited human erythrocyte acetylcholinesterase
...
1
2
3
...