Direct protective effects of poly-unsaturated fatty acids, DHA and EPA, against activation of cardiac late sodium current

@article{Pignier2007DirectPE,
  title={Direct protective effects of poly-unsaturated fatty acids, DHA and EPA, against activation of cardiac late sodium current},
  author={Christophe Pignier and C. Revenaz and Isabelle Rauly-Lestienne and Didier Cussac and Andr{\'e} Delhon and Jean Gardette and Bruno Le Grand},
  journal={Basic Research in Cardiology},
  year={2007},
  volume={102},
  pages={553-564}
}
Polyunsaturated fatty acids (PUFAs) such as docosahexaenoic and eicosapentaenoic acids (DHA, EPA) exert ischemic anti-arrhythmic effects. However, their mechanism of action remains unknown. The present study was designed to investigate their potential effect on the regulation of the late sodium current as the basis for their ischemic anti-arrhythmic activity. Human isoforms of wild-type SCN5A and ΔKPQ-mutated cardiac sodium channels were stably transfected in HEK 293 cells and, the resulting… CONTINUE READING