Direct projections from the periaqueductal gray to the pontine micturition center (M-region). An anterograde and retrograde tracing study in the cat

  title={Direct projections from the periaqueductal gray to the pontine micturition center (M-region). An anterograde and retrograde tracing study in the cat},
  author={Bertil F. M. Blok and Gert Holstege},
  journal={Neuroscience Letters},

Ultrastructural evidence for a paucity of projections from the lumbosacral cord to the pontine micturition center or M‐region in the cat: A new concept for the organization of the micturition reflex with the periaqueductal gray as central relay

It was investigated in cats whether monosynaptic projections from lumbosacral neurons to the M‐region indeed exist, and it was demonstrated that the lateral part of the periaqueductal gray contains neurons projecting to theM‐region.

Afferent projections to the pontine micturition center in the cat

All other parts of the brain that influence micturition have no direct connection with the PMC, as indicated by results in 67 cats.

Direct projections from the lumbosacral spinal cord to Barrington's nucleus in the rat: A special reference to micturition reflex

Clear evidence is provided for a direct projection from the spinal parasympathetic and dorsal commissural nuclei to Barrington's nucleus that could subserve conveying bladder‐filling information from the lumbosacral cord to Barlington's nucleus in the micturition reflex of the rat.

Two pontine micturition centers in the cat are not interconnected directly: Implications for the central organization of micturition

The M and L‐regions have direct long fiber projections to the motoneurons of the bladder muscle and the external urethral sphincter, but they do not influence one another through direct pathways.

Micturition-suppressing region in the periaqueductal gray of the mesencephalon of the cat.

The results suggest that the dorsolateral margin of the rostral PAG includes the micturition-suppressing region that seems to have neural connections with the PMC.

Monosynaptic projections from the lateral periaqueductal gray to the nucleus retroambiguus in the rhesus monkey: Implications for vocalization and reproductive behavior

There exists a strong and direct PAG‐NRA pathway in the rhesus monkey and its lumbosacral projections are likely to be involved not only in vocalization but also in other behaviors, such as receptive posture.



Projections from the periaqueductal gray to the rostromedial pericoerulear region and nucleus locus coeruleus: Anatomic and physiologic studies

The functional anatomy of projections from PAG to the dorsolateral pontine tegmentum is investigated and the organization and synaptic influence of PAG on neurons in the rostromedial pericoerulear region and in LC proper is assessed.

Location and morphology of parasympathetic preganglionic neurons in the sacral spinal cord of the cat revealed by retrograde axonal transport of horseradish peroxidase

Investigation of the distribution and morphology of preganglionic neurons in the sacral parasympathetic nucleus of the cat and the results of other investigations indicate that the SPN has a viscerotopic organization wherein the colon is innervated primarily by cells in the dorsal band and the urinary bladder is innerved primarily bycells in the lateral band.


A lesion in the position of the last, but rather more extensive, produces frequency of micturition as well as the effects observed in 2.

Anatomical and physiological observations on suprapinal control of bladder and urethral sphincter muscles in the cat

In 15 cats injections of 3H‐leucine made in the pontine tegmentum resulted in specific projections to the sacral intermediomedial and intermediolateral cell groups, which contains preganglionic parasympathetic neurons that form the motor supply of the detrusor muscle of the bladder.

Some anatomical observations on the projections from the hypothalamus to brainstem and spinal cord: An HRP and autoradiographic tracing study in the cat

  • G. Holstege
  • Biology
    The Journal of comparative neurology
  • 1987
The hypothalamus is closely involved in a wide variety of behavioral, autonomic, visceral, and endocrine functions, and descending pathways are investigated by horseradish peroxidase and autoradiographic tracing techniques.

The Physiology of the Lower Urinary Tract

This book discusses structure and Innervation in the Human, Comparative Neuromorphology in Animals, and the role of Higher Levels of the Central Nervous System in Bladder Control.

A tetramethylbenzidine/tungstate reaction for horseradish peroxidase histochemistry.

  • R. WeinbergS. V. van Eyck
  • Biology
    The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society
  • 1991
A new modification of this reaction using ammonium paratungstate stabilizer retains high sensitivity while permitting the reaction to be performed at pH 6.0 in isotonic solutions, allowing Nissl-stained sections to retain their peroxidase labeling.