Direct production of fatty alcohols from glucose using engineered strains of Yarrowia lipolytica

  title={Direct production of fatty alcohols from glucose using engineered strains of Yarrowia lipolytica},
  author={Lauren T. Cordova and J. Butler and H. Alper},
  journal={Metabolic Engineering Communications},
Abstract: Fatty alcohols are important industrial oleochemicals with broad applications and a growing market. Here, we sought to engineer Yarrowia lipolytica to serve as a renewable source of fatty alcohols (specifically hexadecanol, heptadecanol, octadecanol, and oleyl alcohol) directly from glucose. Through screening four fatty acyl-CoA reductase (FAR) enzyme variants across two engineered background strains, we identified that MhFAR enabled the highest production. Further strain engineering… Expand
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