• DOI:10.1016/j.mec.2019.e00105
Corpus ID: 214513082

Direct production of fatty alcohols from glucose using engineered strains of Yarrowia lipolytica

@article{Cordova2020DirectPO,
  title={Direct production of fatty alcohols from glucose using engineered strains of Yarrowia lipolytica},
  author={Lauren T. Cordova and J. Butler and H. Alper},
  journal={Metabolic Engineering Communications},
  year={2020},
  volume={10}
}

• Lauren T. Cordova, J. Butler, H. Alper
• Published 2020
• Chemistry, Medicine
• Metabolic Engineering Communications

Abstract: Fatty alcohols are important industrial oleochemicals with broad applications and a growing market. Here, we sought to engineer Yarrowia lipolytica to serve as a renewable source of fatty alcohols (specifically hexadecanol, heptadecanol, octadecanol, and oleyl alcohol) directly from glucose. Through screening four fatty acyl-CoA reductase (FAR) enzyme variants across two engineered background strains, we identified that MhFAR enabled the highest production. Further strain engineering… Expand

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