Direct presentation of nonpeptide prenyl pyrophosphate antigens to human gamma delta T cells.

@article{Morita1995DirectPO,
  title={Direct presentation of nonpeptide prenyl pyrophosphate antigens to human gamma delta T cells.},
  author={Craig T. Morita and Evan M. Beckman and Jack F. Bukowski and Yoshimasa Tanaka and H Band and Barry R. Bloom and David E. Golan and Michael B Brenner},
  journal={Research in immunology},
  year={1995},
  volume={147 5},
  pages={347-53}
}
Human V gamma 2V delta 2+ T cells recognize mycobacterial nonpeptide antigens, such as isopentenyl pyrophosphate, and their synthetic analogs, such as monoethyl phosphate, through a TCR-dependent process. Here, we examine the presentation of these antigens. V gamma 2V delta 2+ T cells recognized secreted prenyl pyrophosphate antigens in the absence of other accessory cells but, under such conditions, required T cell-T cell contact. Recognition required neither the expression of classical MHC… CONTINUE READING
Highly Influential
This paper has highly influenced 12 other papers. REVIEW HIGHLY INFLUENTIAL CITATIONS