Direct preconditioning of cardiac myocytes via opioid receptors and KATP channels.

  title={Direct preconditioning of cardiac myocytes via opioid receptors and KATP channels.},
  author={B. T. Liang and Garrett Gross},
  journal={Circulation research},
  volume={84 12},
Previous studies demonstrated that opioid receptor activation mimics the cardioprotective effect of ischemic preconditioning via KATP channels in the intact heart. However, it is unknown whether this beneficial effect is exerted at the level of the cardiac myocyte or coronary vasculature or is mediated via the sarcolemmal or the mitochondrial KATP channel. Thus, the purpose of the present study was to investigate whether opioid receptor stimulation could mimic the cardioprotective effect of… CONTINUE READING


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