Direct parametric reconstruction in dynamic PET myocardial perfusion imaging: in vivo studies

  title={Direct parametric reconstruction in dynamic PET myocardial perfusion imaging: in vivo studies},
  author={Yoann Petibon and Yothin Rakvongthai and Georges El Fakhri and Jinsong Ouyang},
  journal={Physics in Medicine \& Biology},
  pages={3539 - 3565}
Dynamic PET myocardial perfusion imaging (MPI) used in conjunction with tracer kinetic modeling enables the quantification of absolute myocardial blood flow (MBF). However, MBF maps computed using the traditional indirect method (i.e. post-reconstruction voxel-wise fitting of kinetic model to PET time-activity-curves-TACs) suffer from poor signal-to-noise ratio (SNR). Direct reconstruction of kinetic parameters from raw PET projection data has been shown to offer parametric images with higher… 
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