Direct parametric reconstruction in dynamic PET myocardial perfusion imaging: in vivo studies

@article{Petibon2017DirectPR,
  title={Direct parametric reconstruction in dynamic PET myocardial perfusion imaging: in vivo studies},
  author={Yoann Petibon and Yothin Rakvongthai and Georges El Fakhri and Jinsong Ouyang},
  journal={Physics in Medicine \& Biology},
  year={2017},
  volume={62},
  pages={3539 - 3565}
}
Dynamic PET myocardial perfusion imaging (MPI) used in conjunction with tracer kinetic modeling enables the quantification of absolute myocardial blood flow (MBF). However, MBF maps computed using the traditional indirect method (i.e. post-reconstruction voxel-wise fitting of kinetic model to PET time-activity-curves-TACs) suffer from poor signal-to-noise ratio (SNR). Direct reconstruction of kinetic parameters from raw PET projection data has been shown to offer parametric images with higher… 
Selection of PET Camera and Implications on the Reliability and Accuracy of Absolute Myocardial Blood Flow Quantification
TLDR
The concept of “integral” noise equivalent counts (iNEC) is introduced to compare scanner count-rate performance over the wide dynamic range encountered in MBF imaging with rubidium-82.
Model-Based Reconstruction for Highly Accelerated First-Pass Perfusion Cardiac MRI
TLDR
A model-based FPP-CMR reconstruction approach, which combines image reconstruction and tracer-kinetic modeling, is proposed, which enables very high undersampling rates at each time frame, and thus allows for much higher spatial resolution and coverage than the traditional method.
Clinical quantitative cardiac imaging for the assessment of myocardial ischaemia
TLDR
The use of SPECT, PET, MRI, echocardiography, CT and invasive coronary flow and pressure measurement is summarized, and the relative strengths and weaknesses of each modality are described.
Stress CMR in Known or Suspected CAD: Diagnostic and Prognostic Role
TLDR
Evaluation of the presence and extent of myocardial ischemia through stress CMR (S-CMR) has shown a high rule-in power in detecting functionally significant coronary artery stenosis in patients suspected of CCS, suggesting this multiparametric imaging modality may add significant prognostic value.
Recent methodology advances in fluorescence molecular tomography
TLDR
An overview of the recent methodology advances in FMT is taken, mainly focused on the photon propagation model of FMT based on the radiative transfer equation (RTE), and the reconstruction problem solution consist of forward problem and inverse problem.

References

SHOWING 1-10 OF 142 REFERENCES
Direct 4D Parametric Imaging in Dynamic Myocardial Perfusion PET
TLDR
Direct 4D PET image reconstruction is a viable and very promising approach towards robust parametric MP PET imaging at the individual voxel level and reduces noise by over 50% (matched bias), with further reductions of15% in noise and a factor of five speed-up when optimization transfer was additionally utilized.
A novel approach for direct reconstruction of parametric images for myocardial blood flow from PET imaging.
TLDR
Direct reconstruction of myocardial blood flow shows a high potential for improving the parametric image quality for clinical use and advantage of the proposed method lies in the computation efficiency by shortening the time requirement of the indirect approach and 3%-6% of other direct reconstruction methods.
Direct EM reconstruction of kinetic parameters from list-mode cardiac PET
TLDR
PMOLAR-1T, an EM-based direct reconstruction algorithm, was adapted for parameter estimation from cardiac PET by including in the complete data space an additional dimension to account for the 3 model terms (myocardium, left ventricle, and right ventricles).
Three-dimensional correction for spillover and recovery of myocardial PET images.
TLDR
The new correction method strongly suppresses spillover and recovery effects due to limited resolution in PET perfusion 13NH3-ammonia images.
Direct reconstruction of kinetic parameter images from dynamic PET data
TLDR
Experimental simulations of a rat head imaged in a working small animal scanner indicate that direct parametric reconstruction can substantially reduce root-mean-squared error (RMSE) in the estimation of kinetic parameters, as compared to indirect methods, without appreciably increasing computation.
Study of direct and indirect parametric estimation methods of linear models in dynamic positron emission tomography.
TLDR
This work investigates the methodology to directly reconstruct parametric images in three-dimensional PET when the kinetic model is linear in its parameters and compares with indirectly estimated parametric maps, where the radioactivity distribution was estimated by the filtered back projection and ordered subsets expectation maximization algorithms.
Cardiac motion compensation and resolution modeling in simultaneous PET-MR: a cardiac lesion detection study
TLDR
A list-mode iterative reconstruction framework incorporating both tagged-MR derived non-rigid myocardial wall motion and position dependent detector point spread function (PSF) directly into the PET system matrix is developed incorporating both motion ‘deblurring’ and PSF deconvolution while reconstructing images with all available PET counts.
Direct reconstruction of cardiac PET kinetic parametric images using a preconditioned conjugate gradient approach.
TLDR
A novel approach based on the PCG algorithm to directly reconstruct cardiac PET parametric images from sinograms, and yield better estimation of kinetic parameters than the conventional indirect approach, i.e., curve fitting of reconstructed images.
Direct Estimation of Kinetic Parametric Images for Dynamic PET
TLDR
Recent progress in the development of direct reconstruction algorithms for parametric image estimation for linear and nonlinear kinetic models are reviewed and their properties are discussed.
Whole-body direct 4D parametric PET imaging employing nested generalized Patlak expectation–maximization reconstruction
TLDR
validation on clinical WB dynamic data demonstrated the clinical feasibility and superior Ki CNR performance for the proposed 4D framework compared to indirect Patlak and SUV imaging.
...
...