Direct observation of transition paths during the folding of proteins and nucleic acids

@article{Neupane2016DirectOO,
  title={Direct observation of transition paths during the folding of proteins and nucleic acids},
  author={Krishna Neupane and Daniel A. N. Foster and Derek R. Dee and Hao Yu and Feng Wang and Michael T Woodside},
  journal={Science},
  year={2016},
  volume={352},
  pages={239-242}
}
Transition paths, the fleeting trajectories through the transition states that dominate the dynamics of biomolecular folding reactions, encapsulate the critical information about how structure forms. Owing to their brief duration, however, they have not previously been observed directly. We measured transition paths for both nucleic acid and protein folding, using optical tweezers to observe the microscopic diffusive motion of single molecules traversing energy barriers. The average transit… CONTINUE READING
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