Direct observation of the alkylation products of deoxyguanosine and DNA by fast atom bombardment mass spectrometry.

Abstract

By the methods of fast atom bombardment (FAB) mass spectrometry, thin-layer chromatography and ultraviolet absorption spectroscopy adducts have been studied which are formed by an antitumour alkylating drug thiotepa both in a model system, containing only deoxyguanosine (dGuo), and in DNA. Analysis of the model reaction mixture (dGuo + thiotepa) by FAB mass… (More)

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@article{Andrievsky1991DirectOO, title={Direct observation of the alkylation products of deoxyguanosine and DNA by fast atom bombardment mass spectrometry.}, author={Grigory V Andrievsky and L. F. Sukhodub and T. L. Pyatigorskaya and Oleg A Boryak and Limanskaya OYu and Vadim S Shelkovsky}, journal={Biological mass spectrometry}, year={1991}, volume={20 11}, pages={665-8} }