Direct observation of single molecule conformational change of tight-turn paperclip DNA triplex in solution.

Abstract

DNA triplex modulates gene expression by forming stable conformation in physiological condition. However, it is not feasible to observe this unique molecular structure of large molecule with 54 oligodeoxynucleotides directly by conventional nuclear magnetic approach. In this study, we observed directly single molecular images of paperclip DNA triplexes… (More)
DOI: 10.1007/s12010-008-8390-1

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