Direct observation of preferential processing of clustered abasic DNA damages with APE1 in TATA box and CpG island by reaction kinetics and fluorescence dynamics.

@article{Singh2014DirectOO,
  title={Direct observation of preferential processing of clustered abasic DNA damages with APE1 in TATA box and CpG island by reaction kinetics and fluorescence dynamics.},
  author={Vandana Singh and Bhavini Kumari and Banibrata Maity and Debabrata Seth and Prolay Das},
  journal={Mutation research},
  year={2014},
  volume={766-767},
  pages={56-65}
}
Sequences like the core element of TATA box and CpG island are frequently encountered in the genome and related to transcription. The fate of repair of clustered abasic sites in such sequences of genomic importance is largely unknown. This prompted us to investigate the sequence dependence of cleavage efficiency of APE1 enzyme at abasic sites within the… CONTINUE READING