Direct observation of photolysis-induced tertiary structural changes in hemoglobin.

  title={Direct observation of photolysis-induced tertiary structural changes in hemoglobin.},
  author={Shin-ichi Adachi and S -J Park and Jeremy R.H. Tame and Yoshitsugu Shiro and Naoya Shibayama},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  volume={100 12},
Human Hb, an alpha2beta2 tetrameric oxygen transport protein that switches from a T (tense) to an R (relaxed) quaternary structure during oxygenation, has long served as a model for studying protein allostery in general. Time-resolved spectroscopic measurements after photodissociation of CO-liganded Hb have played a central role in exploring both protein dynamical responses and molecular cooperativity, but the direct visualization and the structural consequences of photodeligation have not yet… CONTINUE READING

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